Professor Matthew Watt
Professor Matthew Watt leads an innovative research program that seeks to identify how defects of lipid metabolism and inter-tissue communication cause obesity-related disorders, and to use this information to discover novel targets that can be transitioned to clinical therapeutics. His team’s research strategy encompasses two major streams:
(1) Target identification- where protein expression is modulated in cultured cells and combined with discovery-based transcriptomic, proteomic and lipidomic approaches with targeted functional cell biology to unravel the regulation of biological functions (metabolism, endocrine function, energy metabolism).
(2) In vivo validation- involves the utilisation of mouse metabolic phenotyping and biochemical assessment of unique transgenic murine models to understand integrative biologysystems. This is followed by pre-clinical studies in human tissues to demonstrate potential therapeutic efficacy.
Professor Watt has authored >130 peer-reviewed manuscripts, has been the recipient of several awards including the Australian Physiological Society AK McIntyre Award and the Deans Award for Excellence in Research (Distinguished Career) at Monash University. He is the Deputy Lead of the Metabolic Disease and Obesity program at Monash and serves as a reviewing editor of the American Journal of Physiology (Endocrinology & Metabolism).